A purpose of this paper is to perform system control for a HIV virus from the viewpoint of system biology. The dosage to use for treatment of the HIV is determined by the appearance of the days of the patient by the experience and the observation data of the doctor, and it may be said that it is the always most suitable dosage. Therefore it is thought that if I can perform system control of the HIV, I can decrease HIV ideally and I can reach the few dosages of the burden for a patient. So, I can contribute to medical care. In this study, I suggest control technique to decide the dosage that used the most suitable servo design method that I used feedback linearization and perform comparison with before method.