This paper develops a small-gain result for large-scale systems composed of hybrid subsystems. It is assumed that the subsystems are input-to-output practically stable (IOpS) and unboundedness observable (UO), and the large-scale hybrid system can be proved to be IOpS and UO as long as the proposed small-gain condition is satisfied. Moreover, if the IOpS assumption on the subsystems is reduced to input-to-output stability (IOS), then the large-scale hybrid system is IOS.