The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute's (OSUCCC- James) is a transformational facility that fosters the collaboration and integration of cancer research and clinical cancer care. Unlike regular facilities, transferring between hospitals requires the staff to occupy accurate and specialized knowledge of the spatial layout for the new hospital. In order to have a smooth transition, the hospital staffs are required to orient themselves and navigate in the new facility in a timely manner. We designed a quest-based game framework to examine the scenario. This data driven framework allows the gaming content be easily updated online by demand. 3D Hospital game is developed based on that framework, which aims at training participants with spatial orientation in the OSUCCC-James. The quests are designed based on several key locations and the daily tasks for the hospital staff. We completed floor 15 in time before the transfer. To measure the effectiveness of our game for prepping the staff during the transition, we surveyed 26 participants and obtained an overall positive feedback. At last, we also examine the obstacles that we encountered as well as future direction.