In this paper, simulating handwork of cut-paste method, a framework of split-merge combination with features of integration of multi-focus image area was built. We also proposed a design of image segmentation on the basis of clarity of images measured, and achieved regional multi-focus vision fusion. According to the standards of image spatial frequency and morphological wavelet transform coefficients, regional image algorithm was design. In the basis of the pixel neighborhood spatial frequency domain as its sharpness measurement, and with the combination of morphological operators, division of clear regional and fuzzy area was directly obtained. And by the multi-focus image that was taken in two different angles and had two printing defects as object image, the actual effect of the double image fusion method was verified.