Fuzzy Handling of Uncertainties in Modeling the Inhibition of Glycogen Synthase Kinase-3 by Paullones | IEEE Conference Publication | IEEE Xplore

Fuzzy Handling of Uncertainties in Modeling the Inhibition of Glycogen Synthase Kinase-3 by Paullones


Abstract:

We consider the problem of modeling the biological activity of inhibitors (belonging to the paullone family) for Glycogen Synthase Kinase-3 (GSK-3). The development of a ...Show More

Abstract:

We consider the problem of modeling the biological activity of inhibitors (belonging to the paullone family) for Glycogen Synthase Kinase-3 (GSK-3). The development of a nonlinear model that establishes the quantitative structure-activity relationship (QSAR) involves an uncertainty regarding the optimal choice of molecular descriptors, structure of the model, number of free model parameters, and so on. This study advocates the use of a fuzzy filter, that mathematically takes into account the underlying uncertainties, for the handling of the uncertainties. The modeling performance is prevented from being adversely affected by the uncertainties with the help of a fuzzy filter. We demonstrate that a robustness of the modeling performance against uncertainties could be achieved using the proposed approach.
Date of Conference: 22-25 September 2007
Date Added to IEEE Xplore: 08 October 2007
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Conference Location: Scottsdale, AZ, USA

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