Integrated circuit (IC) yield prediction which focuses on modelling the IC yield characteristics using manufacturing data is an extremely critical task to pursue, this is because it directly impacts the decision making process to improve manufacturing quality, reliability and reduce cost. In this work, we propose a practical yield prediction approach for system-on-chip (SoC) ICs. To achieve finer granularity in modelling and optimization, and better generality across different SoCs, different functional blocks in the SoC are modelled individually. Partial Least Squares (PLS) and Support Vector Regression (SVR) algorithm are used to build yield models, and the prediction results from both algorithms are analyzed and compared. It is shown that SVR has slightly better prediction performance than PLS. Comparison is also done among different functional blocks as well as different wafer radial regions. Static random access memory (SRAM) block and wafer center appear to have better yield predictability from inline defect data among their peers, which suggests inline monitoring scheme may need to be further optimized to capture potential yield impact to other types of SoC functional blocks or wafer edge region.