Abstract:
DNA microarray technology provides a broad snapshot of the state of the cell by measuring the expression levels of thousands of genes simultaneously. Visualization techni...Show MoreMetadata
Abstract:
DNA microarray technology provides a broad snapshot of the state of the cell by measuring the expression levels of thousands of genes simultaneously. Visualization techniques can enable the exploration and detection of patterns and relationships in a complex dataset by presenting the data in a graphical format in which the key characteristics become more apparent. The purpose of this study is to present an interactive visualization technique conveying the temporal patterns of gene expression data in a form intuitive for nonspecialized end-users. The first Fourier harmonic projection (FFHP) was introduced to translate the multidimensional time series data into a two dimensional scatter plot. The spatial relationship of the points reflect the structure of the original dataset and relationships among clusters become two dimensional. The proposed method was tested using two published, array-derived gene expression datasets. Our results demonstrate the effectiveness of the approach.
Published in: Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003
Date of Conference: 11-14 August 2003
Date Added to IEEE Xplore: 08 September 2003
Print ISBN:0-7695-2000-6