When the unknown degradation is mixed with unknown blurry kernels, how to perform super-resolution operation is an open issue. The mean idea of the existing zero-shot and non-zero-shot methods is to estimate blurry kernel. The effects of these methods depend on the accuracy of the deduced blurry kernel. In this paper, we propose Randomly initialized Zero-Shot Super-Resolution (RZSR) training strategy. RZSR is a zero-shot training method and it allows the network to extract low-resolution image features and generate its counterpart high-resolution images under the interference of degradation algorithms. We further propose two model-agnostic modules which are Adaptive Information Extraction Module (AIEM) and knowledge dictionary. They respectively assist the network to extract features and well fit the data distribution of clear images. RZSR can be applied to any single image super-resolution and video super-resolution models. We prove the generalization ability and superiority of RZSR through a series of experiments.