Unmanned equipment is more and more widely used in complex dangerous scenarios such as emergency rescue. The cooperative operation of manned/unmanned hybrid formation will be the main method at present. This paper proposes a topology analysis and evaluation method of manned/unmanned cooperative equipment systems and constructs a topology model from the logic layer to the physical layer. According to the concepts of degree and betweenness centrality, the key nodes analysis and invulnerability evaluation method of manned/unmanned equipment system are proposed. Finally, the method's effectiveness is verified by simulation, which provides system and data support for dynamic reconstruction and real-time decision-making of manned/unmanned equipment systems.