Social media use among students is increasing day by day, and so does its effects on students’ academic achievement (i.e., Grade Point Average). The relationship between students’ GPA and the use of social media (e.g., Twitter) is not straightforward, because of the hierarchical nature of the data. There is a gap in research that explores the relationship between students’ academic achievement considering hierarchical perspectives. This study attempts to find the relationship between students’ use of Twitter and their GPA. In addition, how their major is related to their use of Twitter. The results suggest that the relationship between Twitter use and students’ academic majors is related. Students from STEM majors have a positive effect than students from social sciences.