Long-term conditions or chronic diseases are multifaceted and challenging. Current treatment options, for patients with long-term conditions, are mainly pharmacological, causing numerous adverse drug events and pressing for alternative management strategies such as personalized interventions. Areas of machine learning, such as deep learning, would enable researchers to develop predictive modelling algorithms, using continuous monitoring and allowing assessing the medical risk for long-term conditions and their related complications. In this paper, we claim that harmonization of data, novel machine learning algorithms, swarm-based technologies, and the involvement of the entire healthcare community will lead to acceptable and effective personalized healthcare. Our proposed approach aims to amplify the intelligence of the healthcare community. Based upon the patients’ characteristics empowers better decisions, personalised medical risk prediction and recommendations of acceptable and effective interventions. Our future work includes the validation of the SwarmAI framework by actively engaging relevant stakeholders.