Light-induced microbubble poration of localized cells | IEEE Conference Publication | IEEE Xplore

Light-induced microbubble poration of localized cells


Abstract:

Molecular delivery into localized NIH/3T3 cells was achieved with microbubbles produced by laser pulses focused on an optically absorbent substrate. The laser-induced bub...Show More

Abstract:

Molecular delivery into localized NIH/3T3 cells was achieved with microbubbles produced by laser pulses focused on an optically absorbent substrate. The laser-induced bubble expansion and contraction resulted in cell poration. The microbubbles are localized at the laser focal point, so molecularMolecular delivery into localized NIH/3T3 cells was achieved with microbubbles produced by laser pulses focused on an optically absorbent substrate. The laser-induced bubble expansion and contraction resulted in cell poration. The microbubbles are localized at the laser focal point, so molecular delivery can be directed at specific localized cells. This was demonstrated with the delivery of 3-kDa FITC-Dextran. Single-cell molecular delivery was achieved, even in the presence of nearby cells. The efficiency of the cell poration was up to 95%, with a corresponding cell viability of 98%. delivery can be directed at specific localized cells. This was demonstrated with the delivery of 3-kDa FITC-Dextran. Single-cell molecular delivery was achieved, even in the presence of nearby cells. The efficiency of the cell poration was up to 95%, with a corresponding cell viability of 98%.
Date of Conference: 03-07 July 2013
Date Added to IEEE Xplore: 26 September 2013
Electronic ISBN:978-1-4577-0216-7

ISSN Information:

PubMed ID: 24110729
Conference Location: Osaka, Japan

References

References is not available for this document.