Employing in-vivo molecular imaging in simulating and validating tumor growth | IEEE Conference Publication | IEEE Xplore

Employing in-vivo molecular imaging in simulating and validating tumor growth


Abstract:

During the last decades, especially via the EU initiative related to the Virtual Physiological Human, significant progress has been made in advancing “in-silico” computat...Show More

Abstract:

During the last decades, especially via the EU initiative related to the Virtual Physiological Human, significant progress has been made in advancing “in-silico” computational models to produce accurate and reliable tumor growth simulations. However, currently most attempts to validate the outcome of the models are either done in-vitro or ex-vivo after tumor resection. In this work, we incorporate information provided by fluorescence molecular tomography performed in-vivo into a mathematical model that describes tumor growth. The outcome is validated against tumor evolution snapshots captured in-vivo using advanced molecular probes in laboratory animals. The simulations are inline with the actual in-vivo growth and although alternative modeling parameters can lead to similar results challenging for additional microscopic information and imaging modalities to drive the in-silico models, they all show that hypoxia plays a dominant role in the evolution of the tumor under study.
Date of Conference: 03-07 July 2013
Date Added to IEEE Xplore: 26 September 2013
Electronic ISBN:978-1-4577-0216-7

ISSN Information:

PubMed ID: 24110990
Conference Location: Osaka, Japan

References

References is not available for this document.