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Localized elasticity measurement for detection of coagulation during HIFU therapy | IEEE Conference Publication | IEEE Xplore

Localized elasticity measurement for detection of coagulation during HIFU therapy


Abstract:

High intensity focused ultrasound (HIFU) treatment is one minimally invasive treatment method for cancer. Visualizing the internal treatment area of a body during HIFU tr...Show More

Abstract:

High intensity focused ultrasound (HIFU) treatment is one minimally invasive treatment method for cancer. Visualizing the internal treatment area of a body during HIFU treatment is required in order to achieve appropriate beam positioning and HIFU dosage. The objective of this work is to develop an ultrasound monitoring system for thermally induced coagulation. Localized motion imaging (LMI) is a monitoring method used to detect a localized mechanical response that is dependent on changes in tissue stiffness caused by thermal coagulation. In LMI, amplitude modulated HIFU causes oscillation of tissues in the HIFU focal area. The elastic modulus at a coagulated area increases and can be detected as an area with decreased oscillation amplitude., Localized control of the oscillation by changing the modulation frequency was conducted to increase the detection sensitivity for small coagulated areas in porcine liver. 2 and 7.5 MHz transducers were employed for HIFU and imaging, respectively. The amplitude modulation frequency was changed in the range from 50 to 200 Hz. The acoustic intensity of HIFU was 2.0 kW/cm2 at the focus and the exposure time was 45 s. The decrease in the amplitude of tissue oscillation at the focal point was detected within 5-10 s of HIFU exposure at the highest modulation frequency. The detected amplitude was decreased to 0.2, which indicates that for LMI, a high modulation frequency is suitable for the detection of small coagulation areas or areas of initial coagulation.
Date of Conference: 03-07 July 2013
Date Added to IEEE Xplore: 26 September 2013
Electronic ISBN:978-1-4577-0216-7

ISSN Information:

PubMed ID: 24111174
Conference Location: Osaka, Japan

References

References is not available for this document.