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Modeling of neonatal hemodynamics during PDA closure | IEEE Conference Publication | IEEE Xplore

Modeling of neonatal hemodynamics during PDA closure


Abstract:

The transition of the fetus at birth to extrauterine life is an extremely complex process. As part of the hemodynamic transition, the closure of ductus arteriosus, a feta...Show More

Abstract:

The transition of the fetus at birth to extrauterine life is an extremely complex process. As part of the hemodynamic transition, the closure of ductus arteriosus, a fetal shunt, is among the key steps to achieve normal postnatal cardiovascular function. However, significant gaps remain in our knowledge pertaining to the hemodynamics of normal ductal closure, and in case of failure of closure, to the hemodynamic consequences and treatment of the patent ductus arteriosus (PDA) in preterm infants. This paper presents a mathematical model of a newborn's cardiovascular system with five peripheral organ systems, the ductus arteriosus, and the baroreceptor reflex. We present the hemodynamic findings during simulation of sudden ductal closure, an event seen in real life when the PDA is closed surgically. The results of our model match the clinical data.
Date of Conference: 25-29 August 2015
Date Added to IEEE Xplore: 05 November 2015
ISBN Information:

ISSN Information:

PubMed ID: 26736650
Conference Location: Milan, Italy

References

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