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Investigating parylene-HT as a substrate for human cell patterning | IEEE Conference Publication | IEEE Xplore

Investigating parylene-HT as a substrate for human cell patterning


Abstract:

We demonstrate, for the first time, how parylene-HT on SiO2 substrates can be used as a human cell patterning platform. We demonstrate this platform with hNT astrocytes, ...Show More

Abstract:

We demonstrate, for the first time, how parylene-HT on SiO2 substrates can be used as a human cell patterning platform. We demonstrate this platform with hNT astrocytes, derived from the human NTera2.D1 cell line. We show how hNT astrocytes are attracted to Parylene-HT and repelled by the SiO2 and are shown to adopt a similar morphology as that attained on standard tissue culture polystyrene. Furthermore, parylene-HT was capable of patterning the astrocytes achieving a ratio of 8:1 for cells on parylene compared to SiO2. Thus, as parylene-HT has similar physical properties to parylene-C with the addition of UV and thermal resistance, parylene-HT represents a desirable alternative substrate for human cell patterning.
Date of Conference: 16-20 August 2016
Date Added to IEEE Xplore: 18 October 2016
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ISSN Information:

PubMed ID: 28268299
Conference Location: Orlando, FL, USA

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