The skin response to high radio frequency has been associated with the human physical condition and most prominently with the stress. The objective of this study is to investigate the possibility to detect mental and light physical stress through the measurement of skin reflectance in the mm-wave/sub-THz band. Two frequency bands have been considered, 75-110 GHz (Band-I) and 325-500 GHz (Band-II), while the measurements have been performed in the three different locations, the arm, the dorsal side of the hand and the fingertip. The measurement setup is discussed in detail and the reflectance spectrum is demonstrated. The results illustrate a difference in skin reflectance under rest and stress in Band-II which ranges from 3.5 dB at the finger to 7 dB at the hand. The outcomes of this study indicate the feasibility of stress detection through skin reflectance measurement and serve as a suggestion for deeper exploration of higher frequency bands.