Knowledge of a cause-and-effect relationship between different physiological systems is helpful in predicting their performance under perturbations, such as orthostatic challenge. The causal coupling between representative signals of the cardiovascular and postural systems under orthostatic challenge remains unknown. Understanding the causal relationship between these two systems is critical, as their interplay is vital to maintain stable upright posture of the human body during quiet standing. In this research, convergent cross mapping (CCM) method was applied to study the causal relationship between the cardiovascular and postural systems previously shown to have coherent activity during quiet standing. Causality was studied between Systolic blood pressure (SBP)-EMG (calf muscles), EMG-COPr (resultant center of pressure), and COPr-SBP signal pairs. These signals were simultaneously recorded in a 5-minute sit-to-stand test from five young healthy participants. Strength of causality was obtained between the signal pairs in a 30-second time segments. The results from this study indicate that there exists a bidirectional causal relationship between the cardio-postural signal pairs, indicating a system level interaction to counter perturbation due to orthostatic challenge. Skeletal muscle pump was found to be driving control of SBP and COPr as the value of EMG→SBP (0.54±0.09) and EMG→COPr (0.52±0.07) were higher than the reverse causality of SBP→EMG (0.19±0.16) and COPr→EMG (0.29±0.16).