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Hybrid automata models of cardiac ventricular electrophysiology for real-time computational applications | IEEE Conference Publication | IEEE Xplore

Hybrid automata models of cardiac ventricular electrophysiology for real-time computational applications


Abstract:

Virtual heart models have been proposed for closed loop validation of safety-critical embedded medical devices, such as pacemakers. These models must react in real-time t...Show More

Abstract:

Virtual heart models have been proposed for closed loop validation of safety-critical embedded medical devices, such as pacemakers. These models must react in real-time to off-the-shelf medical devices. Real-time performance can be obtained by implementing models in computer hardware, and methods of compiling classes of Hybrid Automata (HA) onto FPGA have been developed. Models of ventricular cardiac cell electrophysiology have been described using HA which capture the complex nonlinear behavior of biological systems. However, many models that have been used for closed-loop validation of pacemakers are highly abstract and do not capture important characteristics of the dynamic rate response. We developed a new HA model of cardiac cells which captures dynamic behavior and we implemented the model in hardware. This potentially enables modeling the heart with over 1 million dynamic cells, making the approach ideal for closed loop testing of medical devices.
Date of Conference: 16-20 August 2016
Date Added to IEEE Xplore: 18 October 2016
ISBN Information:

ISSN Information:

PubMed ID: 28269523
Conference Location: Orlando, FL, USA

References

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