Loading [a11y]/accessibility-menu.js
Change in functional networks for transitions between states of consciousness during midazolam-induced sedation | IEEE Conference Publication | IEEE Xplore
Scheduled Maintenance: On Monday, 27 January, the IEEE Xplore Author Profile management portal will undergo scheduled maintenance from 9:00-11:00 AM ET (1400-1600 UTC). During this time, access to the portal will be unavailable. We apologize for any inconvenience.

Change in functional networks for transitions between states of consciousness during midazolam-induced sedation


Abstract:

How brain dynamics change across conscious states, including reliable signatures of the transitions between unconsciousness and consciousness, remains unclear. In this wo...Show More

Abstract:

How brain dynamics change across conscious states, including reliable signatures of the transitions between unconsciousness and consciousness, remains unclear. In this work, we addressed the changes in functional brain networks during self-titrated midazolam sedation using high-density electroencephalography (EEG) in ten subjects. We were particularly interested in the underlying network alterations, identified with graph theory, associated with transitions between states of consciousness. The weighted Phase Lag Index (wPLI) was used as the connectivity estimator between two signals. Based on wPLI, we calculated network properties such as characteristic path length, clustering coefficient, and small-worldness for measuring the integration and segregation of the brain network. We found significant changes in power and wPLI at different levels of consciousness. During unconsciousness, wPLI over the parietal region was higher in the delta band (1-4Hz). The frontal-parietal interaction in the delta band was also stronger during the transition from consciousness to unconsciousness. There was the significant difference of wPLI over the frontal region between consciousness and unconsciousness in the sigma band (12-15Hz). The topological properties across conscious states were significantly changed in the delta band and sigma band. Our results showed parietal brain dynamics is associated with consciousness. Our data also suggest that reversible changes in delta power and connectivity underlie changes in conscious state.
Date of Conference: 11-15 July 2017
Date Added to IEEE Xplore: 14 September 2017
ISBN Information:

ISSN Information:

PubMed ID: 29060032
Conference Location: Jeju, Korea (South)

References

References is not available for this document.