Objective: To study the effect of environmental intervention on chembrain. Methods: SD rats were randomized into the experimental group and the control group. The control group was given peritoneal injection of cyclophosphamide, methotrexate and 5-fluorouracil and the experimental group received the enriched environmental intervention on the basis of the control group. The differences in learning and memory, EMG and dentate gyrus neurons were compared between the two groups. Results: Escape latency in the experimental group was significantly shortened than that in the control group. The number of dentate gyrus NeuN (neuron-specific nuclear protein) positive cells in the experimental group was higher than that in the control group. The experimental group of action ability in the Agile and external stimuli is better than that of the control group. Conclusion: Enriched environmentalintervention can effectively improve the ability of chembrain in learning, memory and ability of action.