An innovative 3-stage miller compensted, cross-coupled load, based photodiode front end readout is designed for glucose monitoring. The Near Infrared Spectroscopy (NIRS) technique is used for the optical sensing of glucose non-invasively. The stable 3-stage open loop amplifier is designed for a gain of 68.3 dB, phase margin of 65°, GBW of 12.6 MHz and has a power consumption of 0.26 mW. The transimpedance amplifier achieves a gain of 84.46 dB, phase margin of 65°, has an input referred noise of 20.4 pA√Hz and consumes 0.55 mW of power from a 3.3 V supply using a 0.18 μm CMOS technology node.