Estimation of the epileptogenic-zone with HFO sub-groups exhibiting various levels of epileptogenicity | IEEE Conference Publication | IEEE Xplore

Estimation of the epileptogenic-zone with HFO sub-groups exhibiting various levels of epileptogenicity


Abstract:

High-Frequency-Oscillations (HFO) are biomarkers of the epileptogenic-zone (EZ) and thus a potential aid in guiding epilepsy-surgery. HFO are normally sub-divided accordi...Show More

Abstract:

High-Frequency-Oscillations (HFO) are biomarkers of the epileptogenic-zone (EZ) and thus a potential aid in guiding epilepsy-surgery. HFO are normally sub-divided according to their oscillating-frequency into Ripples (80-250 Hz) and Fast-Ripples (FR) (250-500 Hz) and are known to also occur in the non-epileptic brain. We address two challenges faced by HFO: firstly, estimating the margins of the EZ using the HFO occurrence-rate from each intracranial EEG channel; secondly, selecting HFO sub-groups with a higher probability of being purely epileptic. We propose the clustering of channels with high HFO occurrence-rates as a deterministic method to delimit the EZ. Additionally, we perform the EZ estimation using 9 sub-groups of HFO; these sub-groups are determined by their temporal and spatial coincidence with intracranial interictal-epileptic-spikes (IES) and are assumed to have varying levels of epileptogenicity. The EZ estimated with the different HFO-sub-groups are compared between themselves and with a proxy of the factually undefinable EZ, namely the resected-volume (RV). The proposed clustering method proved to be deterministic and allowed estimating the EZ for each patient and each HFO-sub-group. Those Ripples assumed to be more epileptogenic occurred in lower numbers than all Ripples but showed the highest correspondence with the RV. All FR sub-groups showed a high specificity to the RV. The proposed clustering method successfully extracted the information from the HFO occurrence-rate to estimate the EZ. The selection of more epileptogenic HFO based on their coincidence with IES proved to be of value for both Ripples and FR.
Date of Conference: 23-27 July 2019
Date Added to IEEE Xplore: 07 October 2019
ISBN Information:

ISSN Information:

PubMed ID: 31946415
Conference Location: Berlin, Germany

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