A low-power radio analog front-end which includes a self-interference (SI) cancellation circuit and a harmonic-rejection power amplifier (HRPA), is proposed to reduce the interaction between a transmitter (TX) and receiver (RX), to enable full-duplex operation. A prototype TSMC device demonstrates more than 30dB SI cancellation over a 4MHz BW and a PA 3^rd and 5^th harmonic reduction of 30dB and 15dB, respectively. The SI cancellation circuitry occupies an active area of 131×112.5μm², consumes 0.25mW from a 1.2V supply and degrades the RX NF by less than 0.6dB.