This paper provides a discussion on the coming technological changes in process automation of networked production systems, which will change the testing procedure. In the smart factory of the future there will be no possibility to reach a test coverage of 100%, assuming a flexible automation with continuous reconfiguration and dynamic changes during runtime. Consequently, large amounts of test cases and powerful algorithms for their prioritization are needed in order to certify the correct functionality of the production systems in the network. A concept is presented on how to analyze and prioritize the enormous amount of test cases resulting from the changes during runtime. The proposed approach for test case selection utilizes information of the product, the process and the status of the for the prioritization and selection.