Monitoring of vital parameters plays a key role in better understanding the clinical condition of hospitalized patients. In this perspective, the virtual biosensor for MEDIcal WARNing precursor (MEDIWARN) aims to help the medical team to take a prompt action in response to the evolution of patients’ health condition. This paper presents the MEDIWARN network architecture and discusses the design challenges that such a system poses. Simulative assessments provide a preliminary evaluation of the system in realistic scenarios.