The use of educational games in an academic context seems to be a superb alternative to traditional learning activities, such as drill-type exercises, in order to engage 21^st-century students. Consequently, this work tries to raise the following objectives: analyze the effectiveness of game-based learning, characterize game elements that may contribute to create playing experiences, comprehend how different player types interact with games and, finally, design interactive games which may create challenges, set goals and provide feedback on progress while motivating learners to study physics and chemistry in a foreign language in the second cycle of Secondary Education (4^th E.S.O. that corresponds to the age of 15–16 years old). Specifically, we have used several Web 2.0 tools (Hot Potatoes, Scratch, What2Learn and SMART Notebook 11) and applications (Microsoft PowerPoint and Microsoft Excel) in order to create the games; and these games are based on the successive contents: laboratory safety, laboratory equipment, stoichiometry, atomic structure, electronic configuration, the periodic table, forces, motion and energy.