This innovative practice paper presents initiatives in the US state of Oklahoma that seek to link STEM education in K-12 public schools to post-secondary programs. In recent years, government agencies in Oklahoma have spearheaded numerous collaborative partnerships among secondary schools, career and technical institutions, and community-based organizations. The primary goal of these partnerships has been to provide coordinated education and training for students in STEM in ways that can increase the numbers of students graduating post-secondary institutions with advanced degrees and certifications in computing and engineering fields. This presentation examines innovative programs in Oklahoma that have unfolded through collaborative partnerships in recent years by exploring new curricular designs, experiential learning initiatives, capacity-building investments, and organizational restructuring that have undergirded school, university, and community partnerships in STEM education in Oklahoma. These programs not only attempt to provide high-quality learning experiences but also aim to support student transitions to post-secondary institutions. This presentation considers preliminary research on the academic, social, and economic outcomes for these programmatic innovations and considers what lessons can be drawn from these initiatives.