The integration of industry and city is an urban planning and development model with mixed functions, which is also an important means to promote the high-quality development of urbanization. Since existing industry-city integration evaluation methods choose the evaluation index from regional statistics data, making it difficult to reflect the information of high spatial granularity. This paper proposed a high-spatial-resolution evaluation method for the integration of industry and city through information entropy, TF-IDF, spatial accessibility and coupling coordination model combining POI and fewer statistics data and took empirical research on 13 administrative districts of Wuhan. The results revealed that the degree of industry-city integration in Wuhan is higher in the city center and lower in the surrounding area, which is consistent with the urbanization law of China; At the district level, there is a mismatch between industrial development and urban function in some districts, and the development of those vulnerable aspects needs to be strengthened. The method proposed in this paper would simplify the complex evaluation index system, have higher geospatial resolution and robustness and provide some references for industry-city integration evaluation.