Developing regions like Pakistan have been facing various challenges to ensure the quality of education. Poor governance and ignorance of merit in different decisions have emerged as key hurdles for Higher Education Institutions (HEIs) towards promoting quality education. In this context, Higher Education Commission (HEC) of Pakistan has established Quality Assurance Agency (QAA), to safeguard the interests of all stakeholders concerning the HEIs. Quality Enhancement Cells (QECs) created across various HEIs of Pakistan to meet the objectives of QAA. Notably, Mehran University of Engineering & Technology (MUET) Jamshoro, being the pioneering Institute, itself initiated the task of adoption of quality assurance practices way before QECs established across various HEIs in Pakistan. MUET acquired ISO 9000 certification in 2003, whereas, QAA created QECs around 2006. Primarily, this paper highlights the impact of MUET's quest in ensuring the provision of quality in higher education by discussing the effectiveness of ISO system in the education sector concerning developing regions, where education systems are facing downfall and how it help in betterfunctioning of QEC of MUET. This paper will highlight the vision and performance of MUET in maintaining its quality standards while facing various pressures from different stakeholders of the society.