In recent years, to improve the quality of medical services in e-health systems, various types of sensors supporting collection and online/offline consultation have appeared in life; effectively facilitating doctors' disease prediction and consultation. However, data in e-health systems come from a wide range of sources and are mostly related to patient privacy. Therefore, how to ensure patient privacy and data confidentiality in data transmission is considered serious issues. In addition, the storage volume of cloud servers continues to grow, and how to guarantee that servers can quickly respond to requests has become a pressing problem. To this end, a privacy-preserving data trans-mission protocol is proposed, which only needs constant times interactions to complete the batching requests. In particular, a lightweight OTnk protocol is designed, employing the idea of matrix transformation, which effectively reduces the number of interactions while protecting the privacy of both communicating parties. The security and performance analysis indicate that the proposed protocol can be instantiated in e-health with high security and efficiency.