The Production Routing Problem (PRP) is concerned with coordinating the manufacturing, holding, distribution, and routing decisions to meet customer demands with an objective of minimizing the total operational costs for a defined period. The PRP can be expanded unaffectedly to concern reverse logistics and return flow processes, which typically consist on collecting used products or recyclable packaging from consumers to the depot or plant for a potential refurbishment, upgrading or recycling. Here, we will model and resolve to optimality the Multiple Plant Production Routing Problem in a Reverse Logistics context.