The deployment of Gigabit Apps owing to their high-bandwidth and low-latency nature pushes the limits of today's end-to-end networking, and reveals new bottlenecks at multiple layers of networking, virtualization, application and user experience. In this paper, we use an exemplar smart health related Gigabit App use case viz., PhysicalTherapy-as-a-Service to show how a multi-layer instrumentation approach of measurement points was critical to successfully deploy our lab-tested App out to residential homes with Google Fiber connections. The salient instrumentation strategies involved an organized co-design method between the App Developer and Network Engineer roles, and a multi-domain network performance monitoring featuring perfSONAR extensions, both of which were realized through our Narada Metrics framework. Our instrumentation strategies engendered a “socio-technical tool” for co-ordination between multi-layer stakeholders in identifying and overcoming the intertwined bottlenecks, and in tuning the App performance. Our results highlight the new instrumentation and measurement challenges to foster multi-layer stakeholder collaboration, and provide rare insights to the budding Gigabit App developer community for performance engineering their Apps to serve residential users.