The ubiquity and flexibility of 5G networks make it an attractive technology to customize for particular needs. In this work, we highlight some of the challenges associated with implementing custom 5G applications in hardware and the growing trend of utilizing high-level synthesis tools to relieve these issues. We present an overview of the 5G resource grid and the MATLAB-Simulink-HDL Coder workflow. We then demonstrate the workflow through an example 5G resource grid transmitter design.