The pupil response to light can reflect various kinds of neural diseases, and different response for two eyes can be analyzed relative afferent pupillary defect. This study presents the novel wearable pupillometer for recording the pupil response and designs the experiment for verifying the synchronization of two cameras. Compared with other devices, the main feature of this study is proven reliable, portable, and wearable for obtaining the pupil response. In addition, our experimental result verify that the pupillometer successfully achieve the function of synchronization.