This paper attempts to study the impact of supply-side structural reform on the total factor productivity of high-tech industries from the perspective of supply-side structural reform affecting potential total factor productivity. Potential total factor productivity is the optimal total factor productivity level that the economy is at an ideal level. To examine the impact of supply-side structural reform on total factor productivity, the most fundamental thing is to examine whether it can increase the potential total factor productivity of high-tech industries. The actual total factor productivity of high-tech industries also fluctuates based on potential total factor productivity. In the end, the impact of supply-side structural reform on potential total factor productivity is examined through the actual data of Liaoning province.