A supply chain is a set of economic elements cooperating together to achieve the same objectives. Riskiness being the main obstacle in supply chains, companies needs to pay attention to risk management. It is the nature of the business activity that determines the degree of required risk management. For example, risk management is one of the pillars of activities related to hazardous materials or nuclear energy. In keeping with that context, this paper presents a literature review on hazard material transportation and then a study case. Risks were analyzed using the Failure Mode, Effects and Criticality Analysis (FMECA) with data coming from a Tunisian company. The results show that the potential effects of the majority of these risks are catastrophic.