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A Microfluidic Chip for Rapidly Controlling Dynamic Biochemical Signals | IEEE Conference Publication | IEEE Xplore

A Microfluidic Chip for Rapidly Controlling Dynamic Biochemical Signals


Abstract:

Dynamic biochemical signals play important regulatory roles in cellular physiological status. As the extracellular environments are very complex, it is difficult to monit...Show More

Abstract:

Dynamic biochemical signals play important regulatory roles in cellular physiological status. As the extracellular environments are very complex, it is difficult to monitor the dynamic biochemical signals in vivo. The microfluidic platform offers new opportunities for generating dynamic biochemical signals in vitro, while existing microfluidic chips always have the limitation of sluggish response times. Here, we report a novel microfluidic chip that can rapidly control dynamic biochemical signals according to the principles of fluid mechanics and mass transport. This microfluidic chip is integrated with a “Christmas tree” structure used to generate linear concentration gradient and a Y-shaped microchannel used to control dynamic biochemical signals. We perform both theoretical analysis and computational fluid dynamic simulations to validate our chip design, and find that the response time to facilitate dynamic concentration gradient is reduced in 1-2 orders of magnitude in contrast to existing devices. Experiments are also being conducted to further demonstrate the validation. Our proposed microfluidic chip can support an ideal platform for studying cell dynamic response in vitro.
Date of Conference: 12-15 June 2018
Date Added to IEEE Xplore: 23 August 2018
ISBN Information:
Electronic ISSN: 1948-3457
Conference Location: Anchorage, AK, USA

References

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