In this paper, we present a bionic sensing system that monitor electromyography (EMG), electrocardiogram (ECG), vibration, and temperature for elderly care. The bionic sensor system contains analog front-end circuits (AFE) including sensor read-out circuit for bio-potential signal pickup, a piezo wave sensing circuit for vibration sensing, a low-power analog-to-digital (ADC) circuit with pulse-width modulation (PWM) digital signal output and a bandgap circuit for temperature tracking. For digital signal processing, we integrated a digital signal controller for AFE control and calibration, an ARM-like microprocessor (SYS32TM) for compression and communication. Finally, a phase-lock loop (PLL) circuit for system clock generating and power on reset, The analog and digital part of the chip has been tape-out separately. Analog circuit is integrated and tested with Xilinx Zynq System-on-Module (SoM). This verification platform is versatile for development while maintaining small form factor for user to wear the system while recording the bio-signals. The sensor system is currently used in elderly care and precision sport study.