As computer systems continue to improve, they also often become larger and more complicated. This may create barriers for individuals with cognitive and learning disabilities, who may find these systems more difficult to use. In this paper, an approach incorporating recent research into interface accessibility for assistive technology is taken to improve the usability of an e-Learning system. By developing a prototype without unnecessary complexities or distractions and by retaining and enhancing those features that are required, this type of e-Learning system can meet the needs of its intended users.