In this paper, we propose two general multiple instance active learning (MIAL) algorithms, multiple-instance active learning with a simple margin strategy (S-MIAL) and multiple- instance active learning with fisher information (F-MIAL), and apply them to the relevance feedback in localized content based image retrieval (LCBIR). S-MIAL considers the most ambiguous picture as the most valuable one, while F-MIAL can utilize the fisher information and analyze the value of the unlabeled pictures by assigning different labels to them. We show that F-MIAL can be integrated more naturally into the multiple instance learning scenario. In experiments, we will show their superior performances on some real-world image datasets.