We propose a fixed-map semi-direct visual odometry (FSVO) algorithm for Micro Aerial Vehicles (MAVs). The proposed approach does not need computationally expensive feature extraction and matching techniques for motion estimation at each frame. Instead, we extract and match ORiented Brief (ORB) features between keyframes and assist-frames. We replace the incremental map generation step in traditional algorithms with fixed map generation at keyframe and assistframe only in our algorithm, resulting in reduced storage memory and higher flexibility for relocalization. Based on the fixed-map, we design a new keyframe selection criterion and a relocalization step. Our algorithm has no limit on the orientation of the camera and reduces drifting effectively. Experimental results on the EuRoC and KITTI datasets show that our algorithm achieves higher precision and robustness than the SVO algorithm.