In this paper, a new single-phase grid-connected photovoltaic (PV) system, based on the five-level S-Packed U-Cell (SPUC5) inverter, is presented. This novel topology requires a minimum number of components while providing a maximum number of voltage levels. The Pulse Width Modulation (PWM) controller is applied to the five-level SPUC inverter in order to insure the self-balancing to the capacitors voltages and fix them to the half of the DC-link voltage. The Incremental Conductance (INC) is the method of controlling the DC/DC converter chosen by the authors to reach the Maximum Power Point (MPP) delivered by the PV array. Simulation results obtained using MATLAB/Simulink environment prove the high efficiency and the good dynamic of the proposed system even in case of radiation changes. The Total Harmonic Distortions (THD) of the output current is less than 5% which corresponds to the grid injection standards even without using filters.