Optimization of equipment configuration is a key technology to improve the efficiency of loading and unloading transfer. Aiming at the allocation problem of rail-sea intermodal transportation handling equipment in container terminals, this paper summarizes the factors that affect the rail-sea intermodal transportation handling equipment configuration, and puts forward the principles that should be considered when configuring the equipment. Under the loading and unloading process of “quay crane, truck, rail crane”, the flow of equipment quantity configuration is designed. It provides an important basis for the equipment configuration of the sea-rail intermodal container port.