Previous works on font generation mainly focus on the standard print fonts where character's shape is stable and strokes are clearly separated. There is rare research on brush hand-writing font generation, which involves holistic structure changes and complex strokes transfer. To address this issue, we propose a novel GAN-based image translation model by integrating the skeleton information. We first extract the skeleton from training images, then design an image encoder and a skeleton encoder to extract corresponding features. A self-attentive refined attention module is devised to guide the model to learn distinctive features between different domains. A skeleton discriminator is involved to first synthesize the skeleton image from the generated image with a pre-trained generator, then to judge its realness to the target one. We also contribute a large-scale brush handwriting font image dataset with six styles and 15,000 high-resolution images. Both quantitative and qualitative experimental results demonstrate the competitiveness of our proposed model.