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Transcriptional cooperativity in molecular dynamics based on normal mode analysis | IEEE Conference Publication | IEEE Xplore

Transcriptional cooperativity in molecular dynamics based on normal mode analysis


Abstract:

Transcriptional regulation is an important component in genetics, with transcriptional factors (TFs) and regulatory DNA regions involved in. In this paper, we observe coo...Show More

Abstract:

Transcriptional regulation is an important component in genetics, with transcriptional factors (TFs) and regulatory DNA regions involved in. In this paper, we observe cooperativity between two significant TFs Oct-l and Sox-2 at their enhancer DNA binding sites in collective motions. Normal mode analysis (NMA) is carried out to simulate the motions of two POU/HMG/DNA complexes, with molecular dynamics (MD) results used as a comparison. We have discovered several types of cooperative interactions between the two TFs in these obtained motions.
Date of Conference: 15-17 July 2012
Date Added to IEEE Xplore: 24 November 2012
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Conference Location: Xi'an, China

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