This study proposes a framework of medicine management system based on the Radio Frequency Identification (RFID). The heavy workloads of the hospital often result in that the nurses give patients the wrong medicine. This situation leads to the patient injury, and even death. In order to improve the quality of health care, this paper integrates the RFID, network and database techniques to develop a graphical medicine management system. In the proposed system, each patient has a RFID tag and each kind of medicine also is encoded to a RFID number. The digital patient information forms contain the medicinal information of each patient. When a nurse gives medicine to a patient, he or she must check the patient's RFID tag and the medicinal number to avoid the situation of taking wrong medicines.