An epileptic seizure is a brief episode of symptoms due to abnormal excessive or synchronous neuronal activity in the brain. Epilepsy is a chronic disorder that affects people of all ages, and one of the most common neurological diseases globally. Epilepsy can have both genetic and acquired causes, nevertheless, the exact mechanism of epilepsy is still unknown. It merits further investigation under which circumstances the brain shifts into the epileptic condition. On the other hand, the influence of the environment on the human organism is one central problem for scientific investigation. It has been suggested previously that incidence of epileptic seizure varies significantly with the weather. Thus, based on the emergency medical service database, this study analyzed the seasonal incidence patterns of epileptic seizure in Taiwan using statistical testing methods. Moreover, various types of meteorological data have been evaluated respectively for their associations with epileptic seizure using the idea of partial correlation.