Agile supply chain management (ASCM) increasingly becomes an effective and significant measure to enhance competitive advantage of modern enterprise that needs the support of agile information system to integrate their supply chain more effectively and quickly. Agility is herein interpreted as the quick creation of supply chain system based on software reuse. A multi-agent based agile supply chain model is developed which separates business logic and transaction process and is implemented to process the enterprise business transaction. A rule-based system is designed to control the enterprise business workflow and multi-agent cooperation which can support effectively the dynamic creation of supply chain, the reengineering of business processes and enhance the distributed information management, software reusability and scalability of the supply chain system.