Fluorescence-based Detection of Uric Acid and Iron using Novel Carbon Nanodots | IEEE Conference Publication | IEEE Xplore

Fluorescence-based Detection of Uric Acid and Iron using Novel Carbon Nanodots


Abstract:

Abnormal level of uric acid is associated with certain biomedical implications such as gout, Alzheimer’s, multiple sclerosis, and renal failure, among others. Furthermore...Show More

Abstract:

Abnormal level of uric acid is associated with certain biomedical implications such as gout, Alzheimer’s, multiple sclerosis, and renal failure, among others. Furthermore, there have been reports of the association between iron (III) and uric acid levels, and simultaneous detection could be crucial to managing or preventing further health complications. In this work, we focus on designing novel carbon nanodots [also called carbon dots (CDs)] for the detection of both the target analyte, i.e., uric acid and iron (III). We developed sulfur, nitrogen-co-doped carbon dots (S, N-co-doped-CDs) that emit blue fluorescence, and it was found that uric acid (UA) and iron (III) quenched the fluorescence when excited at 390nm and 360nm, respectively. Through this fluorescence-based simultaneous detection approach, the limit of detection of UA and Fe3+ were found to be 96.32 μM and 0.13 mM, respectively. This suggests the potential of synthesized CD for the simultaneous detection of Uric acid and Iron (III), specifically in the development of optical-based biosensors.
Date of Conference: 17-20 December 2023
Date Added to IEEE Xplore: 19 March 2024
ISBN Information:
Conference Location: HYDERABAD, India

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